Proteins pack together in crystal as molecular honeycomb, leaving channels, cavities and large holes. We want to exploit these naturally occurring architectures as starting points for nano-engineering. This project addresses the first step - developing algorithms that will mine the Protein Data Bank (http://www.rcsb.org/pdb/home/home.do ) and characterise these architectures in 3D.
The project aims is to develop innovative methods of searching for protein structures in the the Apple OS X Operating system environment and rendering a 3D cartoon on the fly, such that protein structure files can be browsed by 3D cartoon (see the Cover Flow representation in iTunes). Will involve C programming skills.
We wish to develop iPhone apps for a selection of bioinformatic algorithms used in research and teaching. Will require C programming skills, and the student will learn how to write an iPhone app!
In all three projects students will work in a multidisciplinary research environment consisting of biologists, chemists, computer scientists and software developers.